About this Session

In this session you will learn about the rationale for randomized trials and review the major randomized designs used in global health.

Preparing for Class

Focus on the methods and designs of the following articles:

  • Phase 1, Individuals Randomized: Li, J. X., Hou, L. H., Meng, F. Y., Wu, S. P., Hu, Y. M., Liang, Q., … & Wang, W. J. (2016). Immunity duration of a recombinant adenovirus type-5 vector-based Ebola vaccine and a homologous prime-boost immunisation in healthy adults in China: final report of a randomised, double-blind, placebo-controlled, phase 1 trial. The Lancet Global Health.
  • Phase 3, Clusters Randomized: Henao-Restrepo, A. M., Camacho, A., Longini, I. M., Watson, C. H., Edmunds, W. J., Egger, M., … & Draguez, B. (2016). Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!). The Lancet.
  • Stepped-Wedge: Gambia Hepatitis Study Group. (1987). The Gambia hepatitis intervention study. Cancer Research, 47(21), 5782-5787.
  • Equivalence: Mir, F., Nisar, I., Tikmani, S. S., Baloch, B., Shakoor, S., Jehan, F., … & Zaidi, A. K. (2016). Simplified antibiotic regimens for treatment of clinical severe infection in the outpatient setting when referral is not possible for young infants in Pakistan (Simplified Antibiotic Therapy Trial [SATT]): a randomised, open-label, equivalence trial. The Lancet Global Health.
  • Non-inferiority, Study Protocol: Hanlon, C., Alem, A., Medhin, G., Shibre, T., Ejigu, D. A., Negussie, H., … & Lund, C. (2016). Task sharing for the care of severe mental disorders in a low-income country (TaSCS): study protocol for a randomised, controlled, non-inferiority trial. Trials, 17(1), 76.
  • Randomized Encouragement: Devoto, F., Duflo, E., Dupas, P., Parienté, W., & Pons, V. (2012). Happiness on tap: piped water adoption in urban Morocco. American Economic Journal: Economic Policy, 4(4), 68-99.


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